Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
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- creativework.keywords - en
- lentils
- pulses
- colitis
- inflammation
- cytokines
- Dextran sodium sulfate
- creativework.keywords - fr
- lentilles (plantes)
- légumineuses
- colite
- cytokines
- sulfate de dextrane sodique
- dc.contributor.author
- Graf, Daniela
- Monk, Jennifer M.
- Wu, Wenqing
- Wellings, Hannah R.
- Robinson, Lindsay E.
- Power, Krista A.
- dc.date.accessioned
- 2023-04-18T12:24:48Z
- dc.date.available
- 2023-04-18T12:24:48Z
- dc.date.issued
- 2019-11-01
- dc.description.abstract - en
- Lentils (Lens culinaris L.) are a protein-rich plant food, also enriched in fibre and phenolic compounds that may reduce intestinal-associated disease risk. Male C57Bl/6 mice were pre-fed a basal diet (BD) or isocaloric 20% red lentil-supplemented diet (LD) for 3 weeks and acute colitis was induced via dextran sodium sulfate (DSS, 2% w/v in drinking water) for 5 days. LD-fed mice exhibited reduced (i) clinical symptoms, (ii) colon histological damage, and (iii) colonic pro-inflammatory cytokine levels. Additionally, biomarkers of improved colon epithelial barrier integrity and mucosal repair mediators were increased in LD mice (e.g. colonic IL-22, Relmβ, and occludin expression, and serum lipopolysaccharide binding protein). Collectively, the severity of the DSS-induced acute colitis phenotype in mice was attenuated by red lentil dietary supplementation, indicating that lentils may serve as a potential adjuvant dietary therapy in patients with colitis-associated diseases to help limit colonic inflammation and restore barrier function.
- dc.description.abstract-fosrctranslation - fr
- Lentils (Lens culinaris L.) are a protein-rich plant food, also enriched in fibre and phenolic compounds that may reduce intestinal-associated disease risk. Male C57Bl/6 mice were pre-fed a basal diet (BD) or isocaloric 20% red lentil-supplemented diet (LD) for 3 weeks and acute colitis was induced via dextran sodium sulfate (DSS, 2% w/v in drinking water) for 5 days. LD-fed mice exhibited reduced (i) clinical symptoms, (ii) colon histological damage, and (iii) colonic pro-inflammatory cytokine levels. Additionally, biomarkers of improved colon epithelial barrier integrity and mucosal repair mediators were increased in LD mice (e.g. colonic IL-22, Relmβ, and occludin expression, and serum lipopolysaccharide binding protein). Collectively, the severity of the DSS-induced acute colitis phenotype in mice was attenuated by red lentil dietary supplementation, indicating that lentils may serve as a potential adjuvant dietary therapy in patients with colitis-associated diseases to help limit colonic inflammation and restore barrier function.
- dc.identifier.citation
- Graf, D., Monk, J., Wu, W., Wellings H., Robinson, L., & Power, K. (2020). Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice. Journal of Functional Foods, 64,103625, https://doi.org/10.1016/j.jff.2019.103625
- dc.identifier.doi
- https://doi.org/10.1016/j.jff.2019.103625
- dc.identifier.issn
- 2214-9414
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/207
- dc.language.iso
- en
- dc.publisher
- Elsevier
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.subject - en
- Agriculture
- dc.subject - fr
- Agriculture
- dc.subject.en - en
- Agriculture
- dc.subject.fr - fr
- Agriculture
- dc.title - en
- Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
- dc.title.fosrctranslation - fr
- Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journaltitle
- Journal of Functional Foods
- local.article.journalvolume
- 64
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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