Molecular and pathological characterization of classical swine fever virus genotype 2 strains responsible for the 2013–2018 outbreak in colombia

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creativework.keywords - en
Classical swine fever
African and classical swine fever
ASF
CSF
creativework.keywords - fr
Peste porcine classique
Peste porcine africaine et classique
PPA
PPC
dc.contributor.author
Robert, Erin
Goonewardene, Kalhari
Lamboo, Lindsey
Perez, Orlando
Goolia, Melissa
Lewis, Charles
Erdelyan, Cassidy N. G.
Lung, Oliver
Handel, Katherine
Moffat, Estella
Embury-Hyatt, Carissa
Amaya, Nancy Naranjo
Parra, Claudia Patricia Calderón
Rueda, Diana Cristina Gómez
Monroy, Maria Antonia Rincón
Clavijo, Alfonso
Ambagala, Aruna
dc.date.accepted
2023-11-16
dc.date.accessioned
2025-03-18T15:23:18Z
dc.date.available
2025-03-18T15:23:18Z
dc.date.issued
2023-11-24
dc.date.submitted
2023-09-01
dc.description.abstract - en
Classical swine fever (CSF) is a highly contagious transboundary viral disease of domestic and wild pigs. Despite mass vaccination and continuous eradication programs, CSF remains endemic in Asia, some countries in Europe, the Caribbean and South America. Since June 2013, Northern Colombia has reported 137 CSF outbreaks, mostly in backyard production systems with low vaccination coverage. The purpose of this study was to characterize the virus responsible for the outbreak. Phylogenetic analysis based on the full-length E2 sequence shows that the virus is closely related to CSF virus (CSFV) genotype 2.6 strains circulating in Southeast Asia. The pathotyping experiment suggests that the virus responsible is a moderately virulent strain. The 190 nucleotide stretch of the E2 hypervariable region of these isolates also shows high similarity to the CSFV isolates from Colombia in 2005 and 2006, suggesting a common origin for the CSF outbreaks caused by genotype 2.6 strains. The emergence of genotype 2.6 in Colombia suggests a potential transboundary spread of CSFV from Asia to the Americas, complicating the ongoing CSF eradication efforts in the Americas, and emphasizes the need for continuous surveillance in the region.
dc.identifier.citation
Robert, E., Goonewardene, K., Lamboo, L., Perez, O., Goolia, M., Lewis, C., Erdelyan, C. N. G., Lung, O., Handel, K., Moffat, E., Embury-Hyatt, C., Amaya, N. N., Parra, C. P. C., Rueda, D. C. G., Monroy, M. A. R., Clavijo, A., & Ambagala, A. (2023, November 24). Molecular and pathological characterization of classical swine fever virus genotype 2 strains responsible for the 2013–2018 outbreak in Colombia. MDPI. https://doi.org/10.3390/v15122308
dc.identifier.doi
https://doi.org/10.3390/v15122308
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/3531
dc.language.iso
en
dc.publisher - en
MDPI
dc.rights - en
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights - fr
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights.uri - en
https://creativecommons.org/licenses/by/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by/4.0/deed.fr
dc.subject - en
Animal diseases
dc.subject - fr
Maladie animale
dc.subject.en - en
Animal diseases
dc.subject.fr - fr
Maladie animale
dc.title - en
Molecular and pathological characterization of classical swine fever virus genotype 2 strains responsible for the 2013–2018 outbreak in colombia
dc.type - en
Article
dc.type - fr
Article
local.article.journalissue
12
local.article.journaltitle - en
Viruses
local.article.journalvolume
15
local.peerreview - en
Yes
local.peerreview - fr
Oui
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